Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation [Source:SGD;Acc:S000002510]

Chromosome IV: 658,350-661,103 forward strand.

This transcript has 1 exon, is annotated with 21 domains and features, is associated with 60 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YDR103W Show transcript tableHide transcript table