Ubiquitin-binding protein; functions as ubiquitin-Atg8p adaptor in ubiquitin-dependent autophagy; serves as proteaphagy receptor for inactivated 26S proteasomes; contains CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE5 has a paralog, DON1, that arose from the whole genome duplication; human TOLLIP is a functional CUE-domain homolog, can complement yeast null mutant, rescuing hypersensitivity of cue5 null mutant cells to Htt-96Q [Source:SGD;Acc:S000005568]

Chromosome XV: 408,425-409,660 forward strand.

This transcript has 1 exon, is annotated with 21 domains and features, is associated with 25 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YOR042W Show transcript tableHide transcript table