Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress [Source:SGD;Acc:S000001121]

Chromosome VIII: 258,244-261,591 reverse strand.

This transcript has 1 exon, is annotated with 33 domains and features, is associated with 51 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YHR079C Show transcript tableHide transcript table