Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress [Source:SGD;Acc:S000005381]

Chromosome XV: 282,421-285,426 reverse strand.

This transcript has 1 exon, is annotated with 25 domains and features, is associated with 61 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YOL021C Show transcript tableHide transcript table