HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant [Source:SGD;Acc:S000004540]

Chromosome XIII: 115,734-118,898 reverse strand.

This transcript has 1 exon, is annotated with 52 domains and features and is associated with 39 variant alleles.

This transcript is a product of gene YML075C Show transcript tableHide transcript table