Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene [Source:SGD;Acc:S000004133]

Chromosome XII: 427,329-429,386 forward strand.

This transcript has 1 exon, is annotated with 24 domains and features, is associated with 44 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YLR143W Show transcript tableHide transcript table