Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans [Source:SGD;Acc:S000002456]

Chromosome IV: 553,254-555,152 forward strand.

This transcript has 1 exon, is annotated with 15 domains and features, is associated with 62 variant alleles and maps to 29 oligo probes.

This transcript is a product of gene YDR049W Show transcript tableHide transcript table