Saccharomyces cerevisiae (R64-1-1)
Description

Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner [Source:SGD;Acc:S000006070]

Synonyms

APG5

Location

Chromosome XVI: 271,310-272,194 forward strand.

R64-1-1:BK006949.2

About this gene

This gene has 1 transcript (splice variant), 243 orthologues and is a member of 1 Ensembl protein family.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
ATG5YPL149W_mRNA885294aaYPL149W
 
Protein coding
Q12380 NM_001183963.1
NP_015176.1

Gene-based displays