Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant [Source:SGD;Acc:S000006041]
APG6, ATG6, VPT30
Chromosome XVI: 322,071-323,744 forward strand.
R64-1-1:BK006949.2
This gene has 1 transcript (splice variant) and 336 orthologues.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
VPS30 | YPL120W_mRNA | 1674 | 557aa | YPL120W | Protein coding | Q02948 | - | Ensembl Canonical, |