Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly [Source:SGD;Acc:S000005795]

Chromosome XV: 826,385-827,869 forward strand.

R64-1-1:BK006948.2

This gene has 1 transcript (splice variant), 389 orthologues and 4 paralogues.

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