Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress [Source:SGD;Acc:S000005758]
GRPE, YGE1
Chromosome XV: 774,573-775,259 forward strand.
R64-1-1:BK006948.2
This gene has 1 transcript (splice variant), 344 orthologues and is a member of 2 Ensembl protein families.