SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance [Source:SGD;Acc:S000005682]

SIZ2

Chromosome XV: 628,360-630,540 reverse strand.

R64-1-1:BK006948.2

This gene has 1 transcript (splice variant), 317 orthologues, 1 paralogue and is a member of 1 Ensembl protein family.

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