Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS [Source:SGD;Acc:S000005648]

PRF1

Chromosome XV: 552,298-552,887 reverse strand.

R64-1-1:BK006948.2

This gene has 1 transcript (splice variant) and 304 orthologues.

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