Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication [Source:SGD;Acc:S000005615]

VPS12, VPT12, YPT21, YPT51

Chromosome XV: 490,196-490,828 reverse strand.

R64-1-1:BK006948.2

This gene has 1 transcript (splice variant), 362 orthologues, 12 paralogues and is a member of 1 Ensembl protein family.

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