Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress [Source:SGD;Acc:S000005533]
Chromosome XV: 338,938-339,978 reverse strand.
R64-1-1:BK006948.2
This gene has 1 transcript (splice variant), 211 orthologues and 6 paralogues.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
SGT2 | YOR007C_mRNA | 1041 | 346aa | YOR007C | Protein coding | Q12118 | - | Ensembl Canonical, |