RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair [Source:SGD;Acc:S000005493]

HRT2, RBX1, ROC1

Chromosome XV: 70,325-70,690 forward strand.

R64-1-1:BK006948.2

This gene has 1 transcript (splice variant), 98 orthologues, 1 paralogue and is a member of 1 Ensembl protein family.

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