Saccharomyces cerevisiae (R64-1-1)
Description

Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon [Source:SGD;Acc:S000005373]

Synonyms

DER3

Location

Chromosome XV: 301,380-303,035 reverse strand.

R64-1-1:BK006948.2

About this gene

This gene has 1 transcript (splice variant), 247 orthologues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
HRD1YOL013C_mRNA1656551aaYOL013C
 
Protein coding
Q08109 NM_001183267.1
NP_014630.1

Gene-based displays