Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon [Source:SGD;Acc:S000005373]

DER3

Chromosome XV: 301,380-303,035 reverse strand.

R64-1-1:BK006948.2

This gene has 1 transcript (splice variant), 351 orthologues and is a member of 1 Ensembl protein family.

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