Saccharomyces cerevisiae (R64-1-1)
Description

Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation [Source:SGD;Acc:S000005366]

Synonyms

MAK1, MAK17

Location

Chromosome XV: 313,078-315,387 reverse strand.

R64-1-1:BK006948.2

About this gene

This gene has 1 transcript (splice variant), 232 orthologues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
TOP1YOL006C_mRNA2310769aaYOL006C
 
Protein coding
P04786 NM_001183260.1
NP_014637.1

Gene-based displays