Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation [Source:SGD;Acc:S000005366]

MAK1, MAK17

Chromosome XV: 313,078-315,387 reverse strand.

R64-1-1:BK006948.2

This gene has 1 transcript (splice variant) and 354 orthologues.

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