Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids [Source:SGD;Acc:S000004953]

Chromosome XIV: 616,211-618,241 reverse strand.

R64-1-1:BK006947.3

This gene has 1 transcript (splice variant), 51 orthologues, 1 paralogue and is a member of 1 Ensembl protein family.

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