Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1 [Source:SGD;Acc:S000004952]
Chromosome XIV: 618,507-619,565 reverse strand.
R64-1-1:BK006947.3
This gene has 1 transcript (splice variant), 314 orthologues, 2 paralogues and is a member of 2 Ensembl protein families.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
SIS1 | YNL007C_mRNA | 1059 | 352aa | YNL007C | Protein coding | P25294 | NM_001182846.1 NP_014391.1 |