RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration [Source:SGD;Acc:S000004861]

LTN1

Chromosome XIII: 763,351-768,039 reverse strand.

R64-1-1:BK006946.2

This gene has 1 transcript (splice variant) and 356 orthologues.

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