Saccharomyces cerevisiae (R64-1-1)
Description

Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication [Source:SGD;Acc:S000004434]

Synonyms

CMT1, MAR2, STE8

Location

Chromosome XII: 1,019,315-1,022,251 reverse strand.

R64-1-1:BK006945.2

About this gene

This gene has 1 transcript (splice variant), 14 orthologues, 2 paralogues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
SIR3YLR442C_mRNA2937978aaYLR442C
 
Protein coding
P06701 NM_001182330.3
NP_013547.3

Gene-based displays