ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS [Source:SGD;Acc:S000004422]
CIK3, NRD2
Chromosome XII: 993,434-1,000,129 forward strand.
R64-1-1:BK006945.2
This gene has 1 transcript (splice variant), 237 orthologues, 2 paralogues and is a member of 2 Ensembl protein families.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
SEN1 | YLR430W_mRNA | 6696 | 2231aa | YLR430W | Protein coding | Q00416 | NM_001182318.3 NP_013534.3 |