Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; human ADSL can complement yeast ADE13 null mutant [Source:SGD;Acc:S000004351]
BRA1, BRA8
Chromosome XII: 844,282-845,730 forward strand.
R64-1-1:BK006945.2
This gene has 1 transcript (splice variant), 366 orthologues and 2 paralogues.