Saccharomyces cerevisiae (R64-1-1)

Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain [Source:SGD;Acc:S000004301]

Gene Synonyms

CDC25', CTN1


Chromosome XII: 752,224-756,993 reverse strand.


About this gene

This gene has 1 transcript (splice variant), 457 orthologues and 2 paralogues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
P04821 -Ensembl Canonical