Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis [Source:SGD;Acc:S000004193]

Chromosome XII: 550,650-551,960 reverse strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant), 38 orthologues and is a member of 1 Ensembl protein family.

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