Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes [Source:SGD;Acc:S000004012]

Chromosome XII: 184,174-184,926 reverse strand.

R64-1-1:BK006945.2

This gene has 1 transcript (splice variant), 344 orthologues and is a member of 1 Ensembl protein family.

Show transcript tableHide transcript table