Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p [Source:SGD;Acc:S000003925]
KAT11, KIM2, REM50
Chromosome XII: 146,291-147,601 forward strand.
R64-1-1:BK006945.2
This gene has 1 transcript (splice variant), 290 orthologues and is a member of 2 Ensembl protein families.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
RTT109 | YLL002W_mRNA | 1311 | 436aa | YLL002W | Protein coding | Q07794 | NM_001181822.1 NP_013099.1 |