5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease [Source:SGD;Acc:S000001664]

PRP1

Chromosome XI: 107,316-108,599 forward strand.

R64-1-1:BK006944.2

This gene has 1 transcript (splice variant), 336 orthologues and is a member of 2 Ensembl protein families.

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