Saccharomyces cerevisiae (R64-1-1)

Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP) [Source:SGD;Acc:S000001583]


Chromosome XI: 253,697-255,460 reverse strand.


About this gene

This gene has 1 transcript (splice variant) and 333 orthologues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
P34248 -Ensembl Canonical