Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication [Source:SGD;Acc:S000001515]

ORD1

Chromosome XI: 380,065-381,858 reverse strand.

R64-1-1:BK006944.2

This gene has 1 transcript (splice variant), 318 orthologues and 3 paralogues.

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