Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication [Source:SGD;Acc:S000001515]
ORD1
Chromosome XI: 380,065-381,858 reverse strand.
R64-1-1:BK006944.2
This gene has 1 transcript (splice variant), 32 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
IXR1 | YKL032C_mRNA | 1794 | 597aa | YKL032C | Protein coding | P33417 | NM_001179598.3 NP_012893.3 |