Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication [Source:SGD;Acc:S000003550]

Chromosome X: 409,493-411,040 reverse strand.

R64-1-1:BK006943.2

This gene has 1 transcript (splice variant), 300 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

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