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Saccharomyces cerevisiae (R64-1-1)
Description

Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant [Source:SGD;Acc:S000001247]

Gene Synonyms

HTM1

Location

Chromosome VIII: 506,319-508,709 forward strand.

R64-1-1:BK006934.2

About this gene

This gene has 1 transcript (splice variant), 324 orthologues and 2 paralogues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
MNL1YHR204W_mRNA2391796aaYHR204W
 
Protein coding
P38888 -Ensembl Canonical