Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant [Source:SGD;Acc:S000001247]

HTM1

Chromosome VIII: 506,319-508,709 forward strand.

R64-1-1:BK006934.2

This gene has 1 transcript (splice variant), 322 orthologues and is a member of 2 Ensembl protein families.

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