Saccharomyces cerevisiae (R64-1-1)
Description

Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant [Source:SGD;Acc:S000001247]

Synonyms

HTM1

Location

Chromosome VIII: 506,319-508,709 forward strand.

R64-1-1:BK006934.2

About this gene

This gene has 1 transcript (splice variant), 322 orthologues and is a member of 2 Ensembl protein families.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
MNL1YHR204W_mRNA2391796aaYHR204W
 
Protein coding
P38888 NM_001179335.3
NP_012074.3

Gene-based displays