Saccharomyces cerevisiae (R64-1-1)
Description

Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer [Source:SGD;Acc:S000001208]

Synonyms

DBF3, DNA39, RNA8, SLT21, USA2

Location

Chromosome VIII: 429,707-436,948 reverse strand.

R64-1-1:BK006934.2

About this gene

This gene has 1 transcript (splice variant), 371 orthologues and is a member of 1 Ensembl protein family.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
PRP8YHR165C_mRNA72422413aaYHR165C
 
Protein coding
P33334 NM_001179296.1
NP_012035.1

Gene-based displays