SUMO-ligase and SUMO-targeted metalloprotease; involved in DNA repair; removes DNA-protein crosslinks at stalled replication forks during replication of damaged DNA; clears chromatin-bound sumoylated proteins; localizes to single spot on nuclear periphery of mother cells but not daughters; exhibits vacuolar localization upon genotoxic stress; activated by DNA binding; member of minigluzincins protease family with mammalian DVC1/Spartan [Source:SGD;Acc:S000001176]

Chromosome VIII: 371,749-372,558 forward strand.

R64-1-1:BK006934.2

This gene has 1 transcript (splice variant) and 280 orthologues.

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