Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p [Source:SGD;Acc:S000001078]

Chromosome VIII: 180,345-181,760 forward strand.

R64-1-1:BK006934.2

This gene has 1 transcript (splice variant), 235 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

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