Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins [Source:SGD;Acc:S000001040]

Chromosome VIII: 6,401-7,546 forward strand.

R64-1-1:BK006934.2

This gene has 1 transcript (splice variant), 41 orthologues, 12 paralogues and is a member of 2 Ensembl protein families.

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