Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication [Source:SGD;Acc:S000000995]
Chromosome VIII: 100,648-101,883 reverse strand.
R64-1-1:BK006934.2
This gene has 1 transcript (splice variant), 436 orthologues and 1 paralogue.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
LAG1 | YHL003C_mRNA | 1236 | 411aa | YHL003C | Protein coding | P38703 | - | Ensembl Canonical, |