Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication [Source:SGD;Acc:S000003420]

Chromosome VII: 872,044-875,109 reverse strand.

R64-1-1:BK006941.2

This gene has 1 transcript (splice variant), 299 orthologues, 1 paralogue and is a member of 2 Ensembl protein families.

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