Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP) [Source:SGD;Acc:S000003280]

Chromosome VII: 589,826-590,911 forward strand.

R64-1-1:BK006941.2

This gene has 1 transcript (splice variant), 239 orthologues and is a member of 2 Ensembl protein families.

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