Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the MRX complex; function requires sumoylation and phosphorylation; exists as inactive oligomers that are transiently released into smaller active units by phosphorylation; DNA damage triggers Sae2p removal, so active Sae2p is present only transiently; sequence and functional similarity with human CtIP/RBBP8 [Source:SGD;Acc:S000003143]

COM1

Chromosome VII: 173,285-174,322 reverse strand.

R64-1-1:BK006941.2

This gene has 1 transcript (splice variant) and 24 orthologues.

Show transcript tableHide transcript table