Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the MRX complex; function requires sumoylation and phosphorylation; exists as inactive oligomers that are transiently released into smaller active units by phosphorylation; DNA damage triggers Sae2p removal, so active Sae2p is present only transiently; sequence and functional similarity with human CtIP/RBBP8 [Source:SGD;Acc:S000003143]
COM1
Chromosome VII: 173,285-174,322 reverse strand.
R64-1-1:BK006941.2
This gene has 1 transcript (splice variant) and 17 orthologues.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
SAE2 | YGL175C_mRNA | 1038 | 345aa | YGL175C | Protein coding | P46946 | - | Ensembl Canonical, |