Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress [Source:SGD;Acc:S000003005]
Chromosome VII: 427,297-427,947 reverse strand.
R64-1-1:BK006941.2
This gene has 1 transcript (splice variant) and 305 orthologues.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
PNC1 | YGL037C_mRNA | 651 | 216aa | YGL037C | Protein coding | P53184 | - | Ensembl Canonical, |