Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress [Source:SGD;Acc:S000003005]

Chromosome VII: 427,297-427,947 reverse strand.

R64-1-1:BK006941.2

This gene has 1 transcript (splice variant), 177 orthologues and is a member of 2 Ensembl protein families.

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