Saccharomyces cerevisiae (R64-1-1)
Description

Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function [Source:SGD;Acc:S000000745]

Synonyms

NSE2, PSO10

Location

Chromosome V: 120,498-121,301 reverse strand.

R64-1-1:BK006939.2

About this gene

This gene has 1 transcript (splice variant), 56 orthologues and is a member of 1 Ensembl protein family.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
MMS21YEL019C_mRNA804267aaYEL019C
 
Protein coding
P38632 NM_001178834.3
NP_010896.3

Gene-based displays