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Saccharomyces cerevisiae (R64-1-1)

19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000007235]

Gene Synonyms



Chromosome IV: 1,202,128-1,202,397 forward strand.


About this gene

This gene has 1 transcript (splice variant), 15 orthologues and is a member of 1 Ensembl protein family.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
Protein coding
O94742 -Ensembl Canonical