Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2 [Source:SGD;Acc:S000002588]
Chromosome IV: 821,295-825,776 forward strand.
R64-1-1:BK006938.2
This gene has 1 transcript (splice variant), 239 orthologues and is a member of 2 Ensembl protein families.
Name | Transcript ID | bp | Protein | Translation ID | Biotype | UniProt | RefSeq | Flags |
---|---|---|---|---|---|---|---|---|
SCC2 | YDR180W_mRNA | 4482 | 1493aa | YDR180W | Protein coding | Q04002 | NM_001180488.3 NP_010466.3 |