Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism [Source:SGD;Acc:S000002572]

Chromosome IV: 784,871-786,205 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 341 orthologues and is a member of 2 Ensembl protein families.

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