Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation [Source:SGD;Acc:S000002510]

HMD3, NUL3

Chromosome IV: 658,350-661,103 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant) and 31 orthologues.

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