Saccharomyces cerevisiae (R64-1-1)
Description

Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation [Source:SGD;Acc:S000002510]

Synonyms

HMD3, NUL3

Location

Chromosome IV: 658,350-661,103 forward strand.

R64-1-1:BK006938.2

About this gene

This gene has 1 transcript (splice variant) and 31 orthologues.

NameTranscript IDbpProteinTranslation IDBiotypeUniProtRefSeqFlags
STE5YDR103W_mRNA2754917aaYDR103W
 
Protein coding
P32917 NM_001180411.1
NP_010388.1

Gene-based displays