Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans [Source:SGD;Acc:S000002456]

Chromosome IV: 553,254-555,152 forward strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant), 353 orthologues and is a member of 1 Ensembl protein family.

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