Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid [Source:SGD;Acc:S000002364]

OLE2

Chromosome IV: 92,762-93,745 reverse strand.

R64-1-1:BK006938.2

This gene has 1 transcript (splice variant) and 373 orthologues.

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